TARGET Pediatric AML

Join our nationwide, grassroots, collaborative effort to speed the Children's Oncology Group's "highest potential and greatest need" AML research project.

/ 150

AML is one of the poorest prognosis pediatric cancers. Targeted therapies, like modified T-cells, offer new hope. YOU CAN HELP.

Acute myeloid leukemia (AML) is one of the poorest prognosis pediatric cancers. AML therapies have not changed in decades, are notoriously toxic, and harrowing side effects routinely send kids to the ICU. Treatment can be as dangerous as the cancer itself. Young survivors often face significant long-term health issues. Entire families are traumatized and even torn apart. Treating a single, complex patient can cost millions. We can and must do better, FASTER. [SEE VIDEO BELOW]

Cutting-edge, targeted drugs and T-cell therapies offer the greatest hope for breakthroughs. Powerful new tools, like genomic sequencing, can enable the discovery of new targets and expansion our treatment "arsenal". Even old drugs designed for other diseases can be uncovered and repurposed to treat AML! These same tools can help us match the right therapies, in the right combinations, to patients -- delivering personalized, precision medicine. This is important because AML is a complex group of diseases, and every patient's AML can be unique. One "magic bullet" cure for AML is unlikely. Tailored treatment regimens will likely be key to improving outcomes and reducing toxic side effects.

Many of the exciting, new cancer weapons you hear about in the news are "targeted therapies", so they depend on GOOD TARGETS to work. "Target Pediatric AML" seeks to perform deep sequencing on 1000 patient samples to build a comprehensive list of targets for AML patients ages 0-35. Identifying more targets will help us maximize both existing and new treatments, including promising T-cell therapies. The project will also help sick kids NOW by offering genomic sequencing testing to both pediatric AML and biphenotypic (mixed) leukemia patients to uncover all current treatment options and enable precision disease monitoring.

Contact Julie Guillot or Michael Copley (AML parents and TpAML supporters/volunteers) for more information about this project and to discuss how your family or foundation can collaborate. Many thanks to current/early supporters of this work -- the NCI (National Cancer Institute), St. Baldrick's Foundation, Alex's Lemonade Stand, and Hyundai Hope on Wheels. Recent collaborators include the friends and families of Ava Lee, Hazel Altbaum & Mary Stewart Witherspoon, as well as the following: